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[目的]探讨老年乳腺癌患者腋窝淋巴结结外转移情况对其生存状况的影响.[方法]回顾性分析2014年10月至2016年10月于本院收治的106例老年原发浸润性乳腺癌患者的临床病理资料,分析患者肿瘤大小、雌激素受体(ER)和孕激素受体(PR)状态、组织学分化、淋巴结转移阳性数、Ⅰ~Ⅱ水平淋巴结转移个数、腋窝淋巴结转移情况与无复发生存率(RFS)以及总体生存率(OS)等预后情况相关性.采用KapLan-Meier生存分析法,分析单纯腋窝淋巴结患者和腋窝淋巴结转移伴随腋窝淋巴结结外转移患者RFS、OS差异.[结果]单因素分析结果显示,肿瘤大小、淋巴结转移阳性数、Ⅰ~Ⅱ水平淋巴结转移个数影响腋窝淋巴结结外转移,差异均具有统计学意义(P<0.05).Cox多因素分析显示,肿瘤大小、淋巴结阳性转移个数、淋巴转移率、腋窝淋巴结转移情况是发生RFS、OS的危险因素,差异均具有统计学意义(P<0.05).KapLan-Meier生存分析显示,单纯腋窝淋巴结患者RFS为73.68%(42／57),OS为91.22%(52／57);腋窝淋巴结转移伴随腋窝淋巴结结外转移患者的RFS为32.65%(16／49),OS为44.80%(22／49),均低于单纯腋窝淋巴结患者,经Log-Rank检验,差异均具有统计学意义(P<0.05).[结论]肿瘤大小、淋巴结阳性、淋巴结转移个数、淋巴转移率、腋窝淋巴结转移情况影响患者RFS、OS的危险因素,可作为老年乳腺癌患者预后状况的判断指标.“,”[Objective]ToinvestigatetheimpactofaxiLLaryLymphnodemetastasisonthesurvivaLofeLderLywomenwith breastcancer.[Methods]ThecLinicaLandpathoLogicaLdataof106eLderLypatientswithprimaryinvasivebreastcanceradmitted toourhospitaLfrom October2014toOctober2016wereretrospectiveLyanaLyzed.Thetumorsize,estrogenreceptor(ER)and progesteronereceptor(PR)status,histoLogicaLdifferentiation,positivenumberofLymphnodemetastasis,numberofLymph nodemetastasisatLeveLⅠ~Ⅱ,axiLLaryLymphnodemetastasisandrecurrence-freesurvivaLrate(RFS)wereanaLyzed.)Prog-nosticcorreLationssuchasoveraLLsurvivaLrate(OS)wereaLsodiscussed.KapLan-MeiersurvivaLanaLysiswasusedtoanaLyze thedifferencesofRFSandOSbetweenpatientswithsimpLeaxiLLaryLymphnodemetastasisandthosewithextranodaLaxiLLary Lymphnodemetastasis.[ResuLts]UnivariateanaLysisshowedthatthesizeoftumor,thenumberofpositiveLymphnodemetas-tasisandthenumberofLymphnodemetastasisatⅠ~ⅡLeveLhadsignificanteffectontheextranodaLmetastasisofaxiLLary Lymphnode(P<0.05).CoxmuLtivariateanaLysisshowedthatthenumberofLymphnodemetastasisattheLeveLofⅠ~Ⅱhad statisticaLsignificance.Thesizeoftumor,thenumberofLymphnodepositivemetastasis,therateofLymphnodemetastasis andaxiLLaryLymphnodemetastasisweretheriskfactorsofRFS,OS,thedifferencewasstatisticaLLysignificant(P<005). ThesurvivaLanaLysisofKapLan-Meiershowedthattherewasnosignificantdifferencebetweenthetwogroups(P<005).In patientswithaxiLLaryLymphnodeaLone,RFSwas73.68% (42／57),OS,91.22%(52／57).TheRFSinpatientswithaxiLLa-ryLymphnodemetastasiswithaxiLLaryLymphnodeextranodaLmetastasiswas32.65% (16／49),OS44.80%(22／49), whichwasLowerthanthatinpatientswithsimpLeaxiLLaryLymphnodemetastasis.Log-Ranktestwasperformedonthepa-tientswithaxiLLaryLymphnodemetastasisandextranodaLmetastasis.ThedifferencewasstatisticaLLysignificant(P<0.05).[ConcLusion]Tumorsize,positiveLymphnode,numberofLymphnodemetastasis,rateofLymphnodemetastasisandaxiLLary LymphnodemetastasiscanbeusedasriskfactorsofRFS,OSineLderLypatientswithbreastcancer.