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目的 :观察患者接受 TACE结合中药健脾理气治疗后 ,改善厌食、体重下降、骨髓抑制、胃肠道反应及肝功能的作用 ,同时观察其生存时间和有效率。方法 :将 2 2 8例接受 TACE治疗的中晚期肝癌患者 ,采用单盲法随机分成单用 TACE组和 TACE结合中药健脾理气组。结果 :TACE结合中药组 32 3个周期中 ,有 76.2 %食量增加。77.4%体重增加 ,平均每周期体重增长 0 .62± 1 .68kg。血浆白蛋白升高 1 .2± 2 .88/ L。化疗的毒副作用按 WHO抗癌药物急性毒性分级标准 ,出现 II度以上的白细胞下降 2 6%、血红蛋白下降 1 4.9%、胃肠道反应 1 8% ,平均恢复时间分别为6.2± 4.4天、1 0 .4± 9.4天、1 .89± 1 .2天。 6%出现 IV度肝功能损害。临床总有效率为 5 5 .1 %。 2年、3年生存率分别为 35 .6%和 2 6.3%。以上各项指标与 TACE组相比均有显著性差异。结论 :TACE结合中药健脾理气治疗中晚期肝癌 ,可减少化疗的毒副反应 ,全面改善患者化疗期的生活质量 ,延长生存时间。
OBJECTIVE: To observe the effect of TACE combined with Chinese herbal medicine Jianpi Qi on the improvement of anorexia, weight loss, bone marrow suppression, gastrointestinal reaction and liver function, and to observe its survival time and efficiency. Methods: Twenty-eight patients with advanced hepatocellular carcinoma treated with TACE were randomly divided into single TACE group and TACE combined with Jianpi Liqi group by single-blind method. Results: TACE combined with Chinese medicine group 32 3 cycles, 76.2% of food intake increased. 77.4% weight gain, the average weight gain per cycle 0.62 ± 1.68kg. Plasma albumin increased by 1.2 ± 2 .88 / L. Toxicity and side effects of chemotherapy According to the WHO standard of acute toxicity of anticancer drugs, the leukopenia of II degree or above was 26%, the hemoglobin decreased by 4.9% and the gastrointestinal reaction was 18% with an average recovery time of 6.2 ± 4.4 days and 1 0 .4 ± 9.4 days, 1.89 ± 1.2 days. 6% IV degree of liver damage. The total clinical effective rate was 55.1%. The 2-year and 3-year survival rates were 35.6% and 23.3%, respectively. The above indicators and TACE group were significantly different. Conclusion: TACE combined with Chinese herbal medicine Jianpi Qi in the treatment of advanced hepatocellular carcinoma can reduce the toxic and side effects of chemotherapy, improve the quality of life and prolong the survival time of patients during chemotherapy.