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我们用诱导前噬菌体的方法在上海的花园土壤中筛选到一株丁香轮丝链霉菌1588。本文报道该菌的生物学特征及其产生的抗生素1588的发酵、分离及纯化的研究结果。文中还介绍了一种适于对酸碱不稳定的腐草霉素—博莱霉素类抗生素的提取流程,也介绍了用一株对同时存在于抗生素1588发酵液中的其它抗生素不敏感的枯草杆菌进行生物测定的方法。
We selected a strain of Streptomyces lividans 1588 in the garden soil of Shanghai using the method of inducing pre-phage. This article reports the biological characteristics of the bacteria and the results of the fermentation, isolation and purification of the antibiotic 1588 produced. The article also introduced a suitable acid and base of the phleomycin - bleomycins antibiotic extraction process, but also describes the use of a simultaneous presence of antibiotics 1588 fermentation broth of other antibiotics are not sensitive Bacillus subtilis bioassay method.