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一、与抗酸药的相互作用:为了防止长期应用糖皮质激素(简称激素)类药物所致的胃肠反应,传统观点认为,可同服制酸剂和解痉剂,现在临床多与氢氧化铝等药物同用。殊不知,强的松龙与某些制酸剂同用,可降低强的松龙的生物利用度。Muribe等对5例健康人及12例慢性肝炎病人,同时分别给予10毫克强的松龙片剂(60毫升水送服)和60毫升制酸剂(每100毫升中含氢氧化铝3.75克,氢氧化镁4.0克),然后测定强的松龙的血浓度。结果强
First, the interaction with antacids: In order to prevent long-term use of glucocorticoid drugs (referred to as hormone) caused by the gastrointestinal reaction, the traditional view that with the antacids and antispasmodic agent, and now more clinical and hydroxide Aluminum and other drugs with the use. As everyone knows, prednisolone with certain antacids used, can reduce the bioavailability of prednisolone. Muribe and other 5 healthy people and 12 patients with chronic hepatitis were given 10 mg of prednisolone tablets (60 ml of water delivery) and 60 ml of antacids (per 100 ml containing 3.75 g of aluminum hydroxide, 4.0 g of magnesium hydroxide), and then measuring the blood concentration of prednisolone. Strong results