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软组织肉瘤是一种起源不同、形态学复杂多样的恶性肿瘤,其诊断和鉴别诊断一直是病理学家们的主要挑战之一。部分软组织肉瘤具有特异性染色体易位并产生相应的融合基因。通过分子遗传学技术,如传统的遗传学技术、RT-PCR、原位杂交、比较基因组杂交等检测软组织肉瘤特异性染色体改变,对软组织肉瘤的诊断、鉴别诊断及指导临床治疗和预后分析提供了有力的工具。
Soft tissue sarcoma is a malignant tumor with different origins and complex morphological morphology. The diagnosis and differential diagnosis of soft tissue sarcoma have always been one of the major challenges for pathologists. Some soft tissue sarcomas have specific chromosomal translocations and produce the corresponding fusion genes. By molecular genetic techniques, such as traditional genetic techniques, RT-PCR, in situ hybridization, comparative genomic hybridization detection of soft tissue sarcoma specific chromosomal changes, the diagnosis of soft tissue sarcoma, differential diagnosis and guidance of clinical treatment and prognosis analysis provided Powerful tool.