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目的：探讨脑血栓血瘀证与血管内皮细胞纤溶功能及血小板活化程度的关系。方法：检测３０例脑血栓血瘀证患者急性期血浆组织型纤溶酶原激活剂（ｔＰＡ）、纤溶酶原激活剂抑制物（ＰＡＩ）和α颗粒膜蛋白（ＧＭＰ１４０）的含量。结果：脑血栓血瘀证患者与健康对照组的纤溶功能和血小板活化指标有明显差异。患者血浆ｔＰＡ〔（１．３１±０．４７）ｋＵ／Ｌ〕明显低于对照组〔（１．８９±０．５０）ｋＵ／Ｌ〕，而ＰＡＩ和ＧＭＰ１４０〔分别为（８．７５±２．３２）×１０３ＡＵ／Ｌ和（２７．８５±８．６０）μｇ／Ｌ〕则明显高于对照组〔分别为（６．６１±１．６７）×１０３ＡＵ／Ｌ和（１３．３１±３．４２）μｇ／Ｌ〕。结论：脑血栓血瘀证的发病与纤溶功能减退及血小板活化程度的变化密切相关。
Objective: To investigate the relationship between cerebral thrombosis and vascular endothelial fibrinolysis and platelet activation. Methods: The levels of plasma PAI, PAI and GMP140 in 30 patients with cerebral infarction with blood stasis syndrome were measured. Results: There were significant differences in fibrinolytic function and platelet activation between patients with cerebral blood stasis syndrome and healthy controls. The level of plasma tPA (1.31 ± 0.47 kU / L) was significantly lower than that of the control group [(1.89 ± 0.50) kU / L〕, but PAI and GMP140 〔(8.75 ± 2 .32) × 103AU / L and (27.85 ± 8.60) μg / L] were significantly higher than those in the control group [6.61 ± 1.67 × 103AU / L and 13.31 ± 3 .42) μg / L]. Conclusion: The incidence of cerebral blood stasis syndrome is closely related to the changes of fibrinolytic function and platelet activation.