论文部分内容阅读
背景:缺血性脑血管病患者病变区域内存在着存活的、但血流供应不足的脑组织,只要及时恢复血供,就可挽救。新型显像剂99Tcm-HL91脑乏氧显像可以显示脑血流灌注显像为低灌注区的乏氧、缺血但存活的这些脑组织。目的:探讨新型乏氧显像剂99TcmHL91在缺血性脑血管病中的评估价值,为早期干预提供影像学依据。设计:以患者和健康自愿者为研究对象,观察对比的验证性研究。单位:一所大学医院的核医学科和一所省级医院的神经内科,核医学科。对象:2000-03/2001-09在河北省人民医院随机选取门诊和住院的缺血性脑血管病患者18例及健康志愿者4例。方法:对18例临床确诊为缺血性脑血管病患者和4例年龄匹配的健康志愿者进行脑乏氧断层显像,其中临床诊断脑梗死11例,短暂性脑缺血发作(TIA)5例,椎基底动脉供血不足2例,取标记好的99Tcm-HL91555～1110MBq静脉推注,20～30min内行脑乏氧断层显像,17例患者同时进行了CT或MRI检查,11例患者次日行99Tcm-ECD脑灌注断层显像,并对3种方法进行了对比研究。用视觉判定脑血流灌注显像低灌注区域内及周边部位放射性能变化,出现放射性浓聚者,为阳性,未出现放射性浓聚者为阴性,介于两者中间者为临界(用计算机ROI技术与对照侧比较,两侧比值大于25%以上者诊断为阳性,小于者计入阴性组,本研究不?
Background: In ischemic cerebrovascular patients, there exist surviving but not adequate blood supply brain tissue, so long as the blood supply can be resumed in time, it can be saved. The new imaging agent 99Tcm-HL91 cerebral hypoxia imaging can show cerebral perfusion imaging in hypoperfusion perfusion hypoxic, ischemic but survival of these brain tissue. Objective: To evaluate the value of 99TcmHL91 in ischemic cerebrovascular disease and provide imaging evidence for early intervention. Design: Patients and health volunteers were included as study subjects to observe the comparative study. Unit: a university hospital nuclear medicine and a provincial hospital neurology, nuclear medicine. PARTICIPANTS: Eighteen patients with ischemic cerebrovascular disease and four healthy volunteers were randomly selected from outpatients and inpatients in Hebei Provincial People’s Hospital from March 2000 to September 2001. Methods: Eighteen patients with ischemic cerebrovascular disease and 4 age-matched healthy volunteers were enrolled in this study. 11 cases of cerebral infarction, 10 cases of transient ischemic attack (TIA) Cases, vertebrobasilar insufficiency in 2 cases, take a good marker of 99Tcm-HL91555 ~ 1110MBq intravenous injection, 20 ~ 30min brain perfusion imaging, 17 patients at the same time by CT or MRI examination, 11 patients the next day 99Tcm-ECD brain perfusion tomography, and the three methods were compared. Visual judgment of cerebral perfusion imaging in the perfusion area and peripheral parts of the radioactive changes in the performance of radioactive concentration, positive, no radioactive concentration was negative, in between the two as the critical (using computerized ROI Technology compared with the control side, the ratio of more than 25% on both sides were diagnosed as positive, less than the negative group, this study?