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目的探讨血液流变学检测结果与糖尿病肾病的关系及临床意义。方法对118例糖尿病肾病患者(DN)和107例单纯糖尿病未合并肾脏病变患者(NDN)的血液流变学系列检测结果进行分析,并与120例健康体检者为对照组(NC)进行了比较。结果糖尿病肾病患者和单纯糖尿病未合并肾脏病变患者反映血液粘度的系列指标均显著增高,差异有统计学意义(P<0.01)。反映红细胞聚集情况的指数有明显升高,差异有统计学意义(P<0.05),而反映红细胞变形能力的指数有明显降低,差异有统计学意义(P<0.05)。结论糖尿病患者血液粘度升高是微血管病变进而导致糖尿病肾病的重要原因,监测血液流变学检测结果的变化对防治糖尿病肾病有一定意义。
Objective To investigate the relationship between blood rheology test and diabetic nephropathy and its clinical significance. Methods A series of blood rheology tests were performed in 118 patients with diabetic nephropathy (DN) and 107 with untreated diabetic nephropathy (NDN) and compared with 120 healthy controls (NC) . Results The indexes of blood viscosity in patients with diabetic nephropathy and those with simple diabetic nephropathy were significantly increased (P <0.01). The indices reflecting the aggregation of erythrocytes were significantly increased (P <0.05), while the indices reflecting the deformability of erythrocytes were significantly lower (P <0.05). Conclusion The increase of blood viscosity in diabetic patients is an important reason of microangiopathy which leads to diabetic nephropathy. Monitoring the changes of hemorheological results has certain significance in the prevention and treatment of diabetic nephropathy.