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目的探讨体外受精与胚胎移植术(IVF-ET)异位妊娠(EP)患者血β-HCG的动态变化及临床预测应用价值,旨在选择一种有效的预测IVF-ET术后发生EP的实验指标。方法选择2005年1月至2007年1月本院辅助生殖实验室所行206个成功周期,均在胚胎移植后第12、14、16天取静脉血用电化学发光技术检测β-HCG。结果206例中继续妊娠率为71.8%(148例),异位妊娠11.2%(23例)。继续妊娠和异位妊娠在ET后第12、14、16天β-HCG浓度均升高,异位妊娠组β-HCG升高幅度明显低于继续妊娠组,有统计学意义(P<0.05)。继续妊娠组β-HCG值连续检测升高大于1倍者117例占79.0%,异位妊娠23例中β-HCG值连续检测升高大于1倍者3例占13.0%,两组比较有统计学意义(P<0.05)。结论β-HCG的动态变化可以作为预测IVF-ET术后发生EP的有效实验指标。
Objective To investigate the dynamic changes of blood β-HCG in patients with ectopic pregnancy (IVF-ET) and the value of clinical prognosis in vitro fertilization and embryo transfer (IVF-ET), aiming at selecting an effective method for predicting the occurrence of EP after IVF-ET index. Methods From January 2005 to January 2007, 206 successful cycles of assisted reproductive laboratories in our hospital were performed. Venous blood was collected for detection of β-HCG on the 12th, 14th and 16th day after embryo transfer by electrochemiluminescence. Results In 206 cases, the rate of continued pregnancy was 71.8% (148 cases) and ectopic pregnancy was 11.2% (23 cases). The levels of β-HCG on the 12th, 14th and 16th days after ET and ectopic pregnancy were all significantly higher in ectopic pregnancy than in those who underwent continuous pregnancy (P <0.05) . In the third trimester of pregnancy, the β-HCG value in consecutive pregnancy increased by more than 1 time, accounting for 79.0%. In the ectopic pregnancy, the β-HCG value increased more than 1 times in 3 consecutive patients, accounting for 13.0%. There were statistically significant differences between the two groups Significance (P <0.05). Conclusion The dynamic changes of β-HCG can be used as an effective experimental index for predicting the occurrence of EP after IVF-ET.