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目的探索ＩＬ１４Ｒ与ＳＬＥ病程的相关性。方法应用抗ＩＬ１４Ｒ单抗（ＢＡ５）分析了３０例正常人和４３例ＳＬＥ患者外周血淋巴细胞表面ＩＬ１４Ｒ的分布与表达。结果发现ＳＬＥ患者外周血ＩＬ１４Ｒ阳性细胞百分比（２２５６％）明显高于正常人（７８４％）。在活动期和缓解期ＳＬＥ患者中，ＩＬ１４Ｒ表达百分比也具有显著的差异（３２０２％和１３０９％）。结论提示ＢＡ５单抗能拮抗Ｂ细胞激活后ＩＬ１４Ｒ的高表达和ＩｇＧ的分泌。并可能以ＢＡ５单抗阻断和调节ＩＬ１４Ｒ的表达等方面调节Ｂ细胞功能的异常，从而为临床提供新的免疫治疗和检测手段。
Objective To explore the correlation between IL14R and SLE duration. Methods The anti-IL-14R monoclonal antibody (BA5) was used to analyze the distribution and expression of IL-14R on peripheral blood lymphocytes in 30 normal controls and 43 SLE patients. The results showed that the percentage of IL-14R-positive cells in peripheral blood of SLE patients (2256%) was significantly higher than that of normal people (784%). There was also a significant difference in the percentages of IL-14R expression between active and remission SLE patients (3202% and 1309%). Conclusions suggest that BA5 monoclonal antibody can antagonize the activation of B cells IL 14R high expression and IgG secretion. And may be BA5 monoclonal antibody to block and regulate the expression of IL 14R abnormalities in regulating B cell function, so as to provide new clinical immunotherapy and detection tools.