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氟嗪酸(Ofloxacin)是一种结构上与萘啶酸有关的新一代氟代喹诺酮药物.口服给药对多数革蓝氏阴性菌、革蓝氏阳性菌和某些厌氧菌有广谱的抗菌活性.虽然丙氟哌酸(Ciprofloxacin)是另一种体外抗菌活性较好的喹诺酮药物.但是氟嗪酸的药代动力学性质优于丙氟哌酸,氟嗪酸不仅吸收快、高峰血药浓度高好几倍,而且在多数组织和体液中可达到很高的浓度.临床试验表明氟嗪酸对全身性感染和急、慢性尿道感染有效,人体对氟嗪酸的耐受性也较好,至今的临床实践表明细菌对氟嗪酸的耐药现象似乎不易发生.因此氟嗪酸是有价值的,抗菌谱广而口服有效的药物.
Ofloxacin is a new generation of fluoroquinolone drugs structurally related to nalidixic acid. Oral administration has a broad spectrum of most gram-negative, gram-positive and some anaerobic bacteria Antifungal activity Although Ciprofloxacin is another quinolone antibiotic with good antibacterial activity in vitro, the pharmacokinetic properties of trifluoperazine are superior to that of propoxyprofen, which not only absorbs fast but peak blood Drug concentration several times higher, and in most tissues and body fluids can reach very high concentrations of clinical trials show that triptolide for systemic infection and acute and chronic urinary tract infections, the human body is also better tolerance to triflus acid , The clinical practice so far shows that the resistance of bacteria to flurazinic acid does not seem to occur easily, so fluazi acid is a valuable and effective antibacterial spectrum which is orally effective.