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为研究不同悬吊时间对大鼠第３腰椎（Ｌ３）骨质和骨生物力学的影响，选用Ｓ．Ｄ．雄性大鼠４２只，按体重配对分为６组，每组７只。三组为尾吊组，三组为自由活动组。实验期分别为７ｄ、１４ｄ和２１ｄ。结果表明，悬吊１４ｄ大鼠Ｌ３矿盐密度显著增加，悬吊２１ｄ大鼠Ｌ３矿盐密度显著降低，但骨胶原蛋白密度无明显改变。最大载荷、弹性载荷在悬吊７、１４和２１ｄ均显著降低；弹性桡度在７ｄ显著降低。Ｌ３横截面积在悬吊７和１４ｄ显著降低。２１ｄ悬吊大鼠的最大应力和杨氏模量显著降低；悬吊７ｄ大鼠的弹性应力和弹性应变显著降低。骨强度在悬吊７ｄ和１４ｄ大鼠中显著降低，２１ｄ后恢复到对照组水平。骨压缩硬度在２１ｄ悬吊大鼠中显著降低。提示，随着低重力时间的不同，大鼠Ｌ３有矿盐再分布和矿盐丢失现象发生。
In order to study the effect of different suspension time on the bone and bone biomechanics of the third lumbar vertebra (L3) in rats, D. Forty-two male rats were divided into 6 groups according to body weight, with 7 in each group. Three groups for the tail hanging group, three groups for the free group. The experimental period was 7d, 14d and 21d respectively. The results showed that the mineral density of L3 increased significantly on the 14th day of suspension, and the density of mineralization of L3 decreased significantly on the 21th day of suspension, but the density of collagen did not change obviously. The maximum load and elastic load decreased significantly on the 7th, 14th and 21st day after suspension. The elastic radius decreased significantly at 7th day. The L3 cross-sectional area was significantly reduced at suspensions 7 and 14d. The maximum stress and Young’s modulus of the suspended rats on 21d were significantly decreased; the elastic and elastic strains of rats on suspension for 7d were significantly reduced. Bone strength was significantly decreased in the 7d and 14d suspension rats, and returned to the control group after 21d. Bone compression stiffness was significantly reduced in the 21 d suspended rats. Tip, with the different low-gravity time, there is redistribution of mineral salts in the L3 rats and mineral salt loss occurred.