论文部分内容阅读
目的观察活血化瘀养阴方联合FOLFOX4方案治疗中晚期胃癌的临床疗效。方法将60例中晚期(III-IV期)胃癌患者随机分为治疗组和对照组(各30例),对照组采用FOLFOX4化疗方案,治疗组在对照组化疗方案的基础上加用活血化瘀养阴方;两组均以14天为1个治疗周期,连用4个周期后评价近期临床疗效及中医证候疗效,并观察不良反应发生情况。结果治疗组总有效率为46.7%,疾病控制率为83.3%;对照组分别为43.3%和86.7%;组间近期临床疗效比较,差异无统计学意义(P>0.05)。治疗组中医证候有效率为83.3%,对照组为60.0%;组间中医证候疗效比较,差异有统计学意义(P<0.05)。治疗组、对照组分别有5例、7例患者出现不良反应,组间差异无统计学意义(P>0.05)。结论活血化瘀养阴方联合FOLFOX4方案治疗中晚期胃癌,在改善患者临床症状方面优于单纯化疗。
Objective To observe the clinical curative effect of activating blood circulation and resolving yin yin side combined with FOLFOX4 regimen in treating advanced gastric cancer. Methods Sixty patients with advanced stage III-IV gastric cancer were randomly divided into treatment group and control group (30 cases each). The control group was treated with FOLFOX4 chemotherapy. The treatment group was treated with the chemotherapy regimen of activating blood circulation and removing blood stasis Nourishing Yin; both groups were 14 days for a treatment cycle, once every 4 cycles after the evaluation of clinical efficacy and efficacy of traditional Chinese medicine syndrome, and to observe the incidence of adverse reactions. Results The total effective rate was 46.7% in the treatment group and the disease control rate was 83.3%. The control group was 43.3% and 86.7% respectively. There was no significant difference in the recent clinical efficacy between the two groups (P> 0.05). The effective rate of TCM syndromes in the treatment group was 83.3% and that in the control group was 60.0%. There was significant difference in the efficacy of TCM syndrome between groups (P <0.05). There were 5 cases in the treatment group and 7 cases in the control group, respectively. There were no significant differences between the two groups (P> 0.05). Conclusions The combination of promoting blood circulation and removing blood and removing yin yin side with FOLFOX4 regimen in the treatment of advanced gastric cancer is better than simple chemotherapy in improving the clinical symptoms of patients.