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我院于1984年测定70例神经系统疾病患者脑脊液(CSF)的NA含量,其中41例脑血管病已作报道。现将其他29例测定的结果报道如下。 29例中,2例肌蒌缩侧索硬化(ALS)CSF中NA含量最高(0.7865±0.023ng/ml),较13例骨髓病(0.4176±0.044),2例炎性脱髓鞘病(0.3500±0.005)和4例神经根病变(0.3070±0.005)有显著增高(P<0.01～0.05)。8例颅内病变中,CSF中NA含量以脑外伤、脑中线病变及癫痫(0.546～0.790ng/ml)含量较高,其均值(0.5655±0.014),与ALS相似(P>0.05)。Ziegler认为ALS引起CSF中NA含量的增高,系神经元受刺激后谷氨酸脱羧酶(GABA)降低,导致其合成受阻。GABA为脑
In 1984, our hospital measured the NA content of cerebrospinal fluid (CSF) in 70 patients with neurological diseases, of which 41 cases of cerebrovascular disease have been reported. The results of the other 29 cases are reported below. Among the 29 cases, the highest NA content was found in 2 cases of ALS (0.7865 ± 0.023ng / ml), compared with 13 cases of bone marrow disease (0.4176 ± 0.044), 2 cases of inflammatory demyelinating disease (0.3500 ± 0.005) and 4 cases of radiculopathy (0.3070 ± 0.005) (P <0.01 ~ 0.05). In 8 cases of intracranial lesions, the content of NA in cerebrospinal fluid (CSF) was higher than that of ALS (0.5655 ± 0.014) in brain trauma, midline lesion and epilepsy (0.546-0.790ng / ml). Ziegler argues that ALS causes an increase in the NA content in the CSF, a decrease in glutamate decarboxylase (GABA) induced by neurons, resulting in blocked synthesis. GABA for the brain