卵巢癌复发率高与耐药性强以及缺乏个体化治疗的有效预测因子,是其治疗的瓶颈。肿瘤干细胞是存在于肿瘤细胞群体中的少数干细胞样癌细胞亚群,能够凭借正常干细胞所赋予的“自我更新”能力和处于静止期的特性、DNA损伤的修复能力以及高表达膜转运蛋白、逃脱药物的杀伤作用,从而在化疗后导致肿瘤的复发、转移和耐药。就肿瘤干细胞与卵巢癌的复发与耐药方面的相关性研究进行综述。 Ovarian cancer recurrence rate and high resistance and the lack of individualized effective predictors of treatment is the bottleneck of its treatment. Tumor stem cells are a subset of the few stem cell-like cancer cells that exist in the tumor cell population. They are characterized by the “self-renewing” and quiescent properties conferred by normal stem cells, the ability of DNA damage repair, and the high expression of membrane transporters , To escape the killing effect of the drug, resulting in tumor recurrence, metastasis and drug resistance after chemotherapy. This review summarizes the correlation between tumor stem cells and the recurrence and drug resistance of ovarian cancer.