肿瘤的生长和转移与肿瘤区血管生长有密切关系,分期越晚,分化越差,肿瘤内血管密度(MVD)越高。抑制和破坏肿瘤区新生血管的生长,阻断其血液供应导致肿瘤细胞坏死,并阻断其转移,成为治疗实体肿瘤的一种新途径[1]。1997年,O′Reilly等[2]体外实验发现,内皮抑素对牛毛细血管内皮细 The growth and metastasis of tumor are closely related to the growth of tumor in the tumor area. The later the stage of staging, the worse the differentiation, and the higher the intravascular tumor density (MVD). Inhibition and destruction of neovascularization in the tumor area growth, blocking the blood supply leading to tumor necrosis, and blocking the transfer of a solid tumor has become a new way [1]. In 1997, O’Reilly et al [2] in vitro experiments found that endostatin on the capillary endothelial cell thin