自身免疫的现代概念强调抗体在自身免疫病的发生和发展中的作用。除少数单克隆类风湿因子外,大多数和自身成分起反应的自身抗体是多克隆的。因而详细研究这些抗体的结构、特异性和致病作用是极其困难的。新发展起来的杂交瘤技术对自身免疫研究者的主要吸引力,不在于引入一个新概念或免疫机制,而在于对自身抗体在自身免疫病发生和致病机理中的作用,作了更深入的 The modern concept of autoimmunity emphasizes the role of antibodies in the development and progression of autoimmune diseases. With the exception of a few monoclonal rheumatoid factors, most of the autoantibodies that react with their own components are polyclonal. Thus it is extremely difficult to study in detail the structure, specificity and pathogenicity of these antibodies. The main attraction of the newly developed hybridoma technology to autoimmunity researchers lies not in the introduction of a new concept or immunization mechanism but rather in the role of autoantibodies in the pathogenesis and pathogenesis of autoimmune diseases.