药物或外来物的代谢研究,可采用各种离体器官(包括肝、肺、小肠、肾、心、睾丸等),其中因肝脏微粒体内含有多种功能的药酶,能使外来物质起非特异性代谢故肝脏是机体对药物进行代谢的主要器官,而肝脏灌流则是研究药物代谢的主要方法之一。从实验技术上,它又分为在位试验与离体试验。前者对药物代谢研究范围,虽已限于肝脏,但仍无法避免受肝门静脉和动脉血流以及神经元和激素等内源性物质对肝脏代谢的影响,后者则不受上述因素影响, Drugs or foreign body metabolism research, can use a variety of isolated organs (including liver, lung, small intestine, kidney, heart, testes, etc.), which due to liver microsomes containing multiple functions of drug enzymes, Heterosexual metabolism so the liver is the body’s main organ for the metabolism of drugs, and liver perfusion is the study of drug metabolism, one of the main ways. From the experimental technology, it is divided into in-position test and in vitro test. The former study of drug metabolism, although limited to the liver, but still can not be avoided by hepatic portal vein and arterial blood flow and neurons and hormones and other endogenous substances on liver metabolism, the latter are not affected by the above factors,