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本文运用大白鼠离体心脏灌注装置观察甲基强的松龙对缺氧所致心肌细胞膜通透性变化的防治作用。将18只大白鼠分成缺氧对照组、在缺氧灌注液中含有0.01mM 和0.10mM 甲基强的松龙三组。结果显示在缺氧对照组中心肌细胞中线粒体等结构均有变化,镧颗粒进入细胞内且 CPK 释放增加;而在甲基强的松龙的两组中镧颗粒均局限在心肌细胞外,CPK 释放不如缺氧对照组明显。提示甲基强的松龙具有防治心肌缺氧所致心肌细胞膜通透性变化的效应.
In this paper, isolated rat cardiac perfusion device was used to observe the effect of methylprednisolone on the permeability of myocardial cells induced by hypoxia. Eighteen rats were divided into three groups: hypoxia control group, 0.01mM and 0.10mM methylprednisolone. The results showed that mitochondria and other structures were changed in the myocardial cells of hypoxic control group, lanthanum particles into the cells and CPK release increased, while in methylprednisolone group lanthanum particles were confined outside the cardiomyocytes, CPK Release as hypoxia control group significantly. It is suggested that methylprednisolone has the effect of preventing and treating the change of myocardial cell membrane permeability induced by myocardial hypoxia.