α-苯基 - β-对甲氧基苯基丙烯酸 (1 )为菲并联啶类生物碱开环类似物中间体。菲并联啶类生物碱具有抗肿瘤、抗真菌及抗细菌作用[1,2 ] 。此类生物碱来源有限 ,提取工艺复杂 ,毒副作用较多。为保留其药理活性 ,降低毒副作用 ,进行了结构改造。本文报道的 1合成方法 ,较文献法有 α-Phenyl-β-p-methoxyphenylacrylic acid (1) is a phenanthridinium alkaloid ring-opened analogue intermediate. Phenanthridine pyridine alkaloids with anti-tumor, anti-fungal and anti-bacterial effect [1,2]. Such alkaloids have limited sources, complicated extraction processes and more side effects. In order to retain its pharmacological activity, reduce the side effects, the structural transformation. This article reported a synthesis method, compared with the literature method