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“崔教授,我发现了一件奇怪的事情。”秦丽雅推门进来,没等坐稳,就开始向崔征诉苦:“为了制取抗体,我给16只BALB／c小鼠打了S180细胞,准备抽腹水,结果有一只小鼠的肚子一直没变大。我又试过一次,还是不行。”“你肯定你给它注射S180了?”“第一次我不敢肯定,但第二次我肯定注射了。”“你给它注射了多少剂量的S180?”一般情况下这个问题简直多余,因为S180是最厉害的小鼠癌细胞系之一,通常只需要几千个细胞就能让小鼠产生癌变。这个细胞系来自一只瑞士小鼠的软组织肉瘤,其表面没有MHC,也就是“主要组织相容性复合体”。MHC是任何正常细胞表面都有的标记性蛋白质,免疫细胞就靠它来识别敌我,器官移植后发生的异体排斥现象也是因为它。没了MHC,S180就可以肆无
“Cui Professor, I found a strange thing.” Qin Liya push the door came in, did not wait firmly, began to complain Cui bitter: “In order to make antibodies, I gave 16 BALB / c mice hit S180 cells, ready to ascites, the results of a mouse stomach has not changed. I tried again, or not. ”“ You sure you give it injection S180? ”“ The first time I am not sure, but The second time I am sure I’m injecting. ”“ How many doses did you give to the S180? ”This is generally a superfluous problem, since S180 is one of the most powerful cancer cell lines in mice and usually requires only a few thousand cells Mice can cause cancer. This cell line comes from a soft-tissue sarcoma of a Swiss mouse that has no MHC on its surface, the “major histocompatibility complex.” MHC is a marker protein on the surface of any normal cell. Immune cells rely on it to identify enemies and enemies. It is also because of allogeneic rejection that occurs after organ transplantation. No MHC, S180 can be wantonly