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目的探讨胃癌组织中表皮生长因子受体(EGFR)、人表皮生长因子受体-2(HER-2)、磷脂酰肌醇3激酶(PI3K)和磷酸酶基因(PTEN)蛋白的表达及临床意义。方法 70例手术切除胃癌标本作为观察组,70例病例癌旁组织作为对照组,通过免疫组织化学方法对PI3K、EGFR、PTEN以及HER-2蛋白进行检测,了解其在胃癌组织中的具体表达情况。结果观察组与对照组的EGFR蛋白表达阳性率比较,差异无统计学意义(P>0.05)。与对照组比较,观察组的HER-2、PI3K蛋白表达阳性率以及PTEN蛋白表达缺失率均较高,差异具有统计学意义(P<0.05)。结论临床上在治疗胃癌时,对PI3K、EGFR、PTEN以及HER-2蛋白进行联合检测,可以为胃癌分子靶向治疗药物的选择提供帮助,有助于临床治疗水平的提高。
Objective To investigate the expression and clinical significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER-2), phosphatidylinositol 3 kinase (PI3K) and phosphatase (PTEN) . Methods Seventy patients underwent resection of gastric cancer specimens as observation group and 70 cases of paracancerous tissues as control group. The expressions of PI3K, EGFR, PTEN and HER-2 protein were detected by immunohistochemical method to find out their specific expression in gastric cancer . Results There was no significant difference in the positive rate of EGFR protein between observation group and control group (P> 0.05). Compared with the control group, the positive rates of HER-2 and PI3K in the observation group and the loss of PTEN protein expression in the observation group were higher (P <0.05). Conclusions Combined detection of PI3K, EGFR, PTEN and HER-2 protein in clinical treatment of gastric cancer can help to select molecular targeted therapy for gastric cancer and is helpful to improve the clinical treatment.