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本文采用了能反映流体轴向扩散的大型液相色谱分离过程数学模型，应用计算机模拟分析蔗糖和还原糖的色谱分离过程，从吸附剂吸附容量和柱装填密度两个方面；考察柱吸附容量对大型色谱分离的产率和回收率的影响。研究结果表明：在色谱柱中流体线速度恒定的条件下对多组分分离，回收率是随吸附剂吸附容量以及床层装填密度的增大而增大的；产率先随吸附剂吸附容量的增大而增大，而在出现峰值后下降；随着床层装填密度的增大，产率增加，但与此同时轴向扩散系数也增大，从而降低分离效率，导致在较高装填密度的范围内产率增力。的幅度减少。在相同的吸附剂用量下，采用短柱高装填密度的色谱柱将比长柱低装填密度色谱柱能获得更高的回收率和产率。
In this paper, a mathematical model of large-scale liquid chromatographic separation process that reflects the axial diffusion of fluids was used. The chromatographic separation process of sucrose and reducing sugar was analyzed by computer simulation. The adsorption capacities of adsorbents and column packing densities were investigated. Effect of large chromatographic separation on yield and recovery. The results show that the separation of multicomponent components is achieved with a constant linear velocity of the fluid in the column, and the recovery rate increases with the adsorbent capacity and bed packing density. The yield first increases with the adsorbent capacity Increases with increasing, but decreases after the peak appears. With the increase of bed packing density, the yield increases, but at the same time the axial diffusion coefficient also increases, thus reducing the separation efficiency, resulting in higher packing density Productivity gains in the range. The decrease of amplitude. At the same sorbent loading, columns with higher column packing density will achieve higher recovery and yield than longer column packing density columns.