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目的:探讨蜘蛛香环烯醚萜治疗肠易激综合征(IBS)的作用机制。方法:雄性SD大鼠60只,分为空白组、模型组、氟西汀组和蜘蛛香环烯醚萜高、中、低剂量组(24.92,12.46,6.23 mg.kg-1),各10只,以慢性应激加孤养的方法造模,观察蜘蛛香环烯醚萜对各组结肠、血清和下丘脑中5-HT和5-HIAA含量的影响。结果:模型组结肠、血清含量均显著上升,而下丘脑5-HT含量显著下降,5-HIAA和5-HT/5-HIAA变化则不太明显,蜘蛛香环烯醚萜各剂量组对结肠和血清中的5-HT有明显的降低作用,对下丘脑中5-HT则有升高作用。对5-HIAA的影响则无明显变化规律,而对结肠和血清中5-HT/5-HIAA则表现为降低作用。结论:蜘蛛香环烯醚萜改善IBS症状的机制可能与调节从胃肠到中枢的5-HT水平有关。
Objective: To investigate the mechanism of spilantol iridoid treatment of irritable bowel syndrome (IBS). Methods: Sixty male Sprague-Dawley rats were randomly divided into blank group, model group, fluoxetine group and high, medium and low doses of arachidonic group (24.92,12.46,6.23 mg.kg-1) Only chronic stress and loneliness modeling, to observe the spiders iridoid on the colon, serum and hypothalamus 5-HT and 5-HIAA content. Results: The content of colon and serum in model group increased significantly, while the content of 5-HT in hypothalamus decreased significantly, while the change of 5-HIAA and 5-HT / 5-HIAA was not obvious. And serum 5-HT has a significant role in the hypothalamus, 5-HT has an elevated role. The effect on 5-HIAA showed no obvious change, but decreased to 5-HT / 5-HIAA in colon and serum. CONCLUSIONS: The mechanism by which spironation iridoid may improve IBS symptoms may be related to the regulation of 5-HT level from gastrointestinal to central.