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近年来,COPD患者下呼吸道的细菌菌丛的作用一直在讨论中。正常人下呼吸道是无菌的,但在稳定期COPD(sCOPD)患者下呼吸道的微生物样本中发现有细菌生长,最常见的细菌是流感嗜血杆菌、肺炎双球菌、卡它莫拉菌,并且这些阳性标本的细菌存在情况在加重期COPD(eCOPD)患者中更高,暗示了细菌感染的作用。当然,COPD下呼吸道的细菌感染的大多数研究是用痰培养或者支气管抽吸物,样本通常有上呼吸道菌丛污染。保护性样本刷(PSB)在取下呼吸道样本
In recent years, the role of bacterial flora in the lower respiratory tract of patients with COPD has been under discussion. Normal lower respiratory tract is sterile, but bacterial growth is found in microbial samples of the lower respiratory tract in patients with stable COPD (sCOPD), the most common being Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, and The bacterial presence of these positive specimens is higher in patients with exacerbated COPD (eCOPD), suggesting the role of bacterial infection. Of course, the majority of bacterial infections in the lower respiratory tract of COPD are sputum cultures or bronchial aspirates, and the sample is usually contaminated with upper respiratory flora. Protective Sample Brush (PSB) Remove the airway sample