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试验用20只成年新西兰白兔(3～4kg)。麻醉后,于无菌情况下,用外科刀做角膜中央半厚切口。再用睫状体剥离小铲在角膜实质中层水平作一放射状角膜袋,伸延至角膜缘。将内含1μg前列腺素的缓释聚合物小球放入角膜实质袋内,距角膜缘1.5mm。术后每日给予妥布霉素(tobramycin)眼膏,防止感染。每天每只兔接受腹膜内注射Hanks平衡盐溶液100ml,内加或不加30mg的氨氯吡脒(amiloride)。对照组中一只眼因作角膜实质袋时穿孔,被除外。5天后,静脉注射致死量
Twenty adult New Zealand white rabbits (3-4 kg) were tested. After anesthesia, under sterile conditions, with a surgical knife to do the central corneal incision. Re-use ciliary body spatula in the middle of the cornea for a radial radial corneal pocket, extending to the limbus. Will contain 1μg of prostaglandin sustained release polymer beads into the cornea parenchyma bag, 1.5mm from the limbus. Post daily tobramycin eye ointment to prevent infection. Each rabbit receives 100 ml of Hanks balanced salt solution intraperitoneally per day, with or without 30 mg of amiloride. One eye in the control group was perforated except for the cornea parenchyma. Five days later, lethal dose intravenously