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Madeley和Cosgrove在1975年通过电子显微镜的观察,从腹泻的婴儿粪便中第一次发现直径为28nm的星状病毒。本实验选择有低水平星状病毒抗体或没有抗体的志愿者,年今18—50岁,口服0.1ml含有星状病毒的粪便提取物或滤液的接种物,在双盲的情况下每天检查有无头痛、不适、噁心、厌食、腹部不适或腹痛等症状,用口表测体温2次及记录排便次数、性质和有无呕吐。当实验者认为他们的症状和胃肠道有关,即使是可疑有关时就收集粪便。由于吞服了含在粪便提取物和滤液中的星状病毒,使成年志
Madeley and Cosgrove observed by electron microscopy in 1975 that for the first time a 28-nm-diameter astrovirus was found in diarrhea from infant droppings. This experiment chose low-level astrovirus or antibody-free volunteers, aged 18-50 years old, oral administration of aspartate extract or filtrate containing 0.1ml of ascites inoculum, double check in the case of double blind every day No headache, discomfort, nausea, anorexia, abdominal discomfort or abdominal pain and other symptoms, mouth temperature measured with a table 2 times and record the number of defecations, the nature and with or without vomiting. When experimenters think their symptoms are related to the gastrointestinal tract, collecting stool even when suspicious is relevant. As a result of swallowing the astrovirus contained in faecal extract and filtrate, adult choroid