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目的通过检测血浆中的可溶型不规则趋化因子(sFKN)的水平,探讨其与类风湿关节炎(RA)发病的关系及其与疾病活动的相关性。方法应用ESLIA方法分别测定30例RA活动组、30例RA缓解组及30名健康对照组的血浆sFKN水平,并同时应用ESLIA方法测定类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体及记录病程、晨僵时间、关节压痛数、关节肿胀数、Ritchter指数等活动性指标。结果 RA组血浆sFKN水平明显高于健康对照组,且RA活动组血浆sFKN明显高于RA缓解组(均P﹤0.05)。血浆sFKN水平与RF、抗CCP抗体及ESR、C反应蛋白(CRP)、关节肿胀数、关节压痛数、Ritcher指数等活动性指标成显著正相关性(均P<0.01),与晨僵时间、病程无相关性(均P>0.05)。结论血浆sFKN可能参与了RA的病理生理过程且有助于RA的诊断,并可作为判断RA活动性的重要指标之一。
Objective To investigate the relationship between sFKN and the pathogenesis of rheumatoid arthritis (RA) by detecting soluble sFKN in plasma. Methods Serum levels of sFKN in 30 patients with RA, 30 patients with RA remission and 30 healthy controls were measured by ESLIA method. At the same time, ESLIA was used to determine the levels of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) Antibodies and recording of disease course, morning stiffness time, joint tenderness, joint swelling, Ritchter index and other activity indicators. Results The level of sFKN in RA group was significantly higher than that in healthy control group. The level of sFKN in RA group was significantly higher than that in RA group (all P <0.05). Plasma sFKN levels were positively correlated with RF, anti-CCP antibody, ESR, CRP, joint swelling, joint tenderness and Ritcher index (all P <0.01) No correlation was found between the two groups (all P> 0.05). Conclusion Plasma sFKN may be involved in the pathophysiological process of RA and contribute to the diagnosis of RA. It may be used as an important index to judge the activity of RA.