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目的:回顾性分析狼疮性肾炎(LN)患者肾移植的临床特点及远期预后。方法:收集本中心1994年至2014年明确诊断为LN并进行肾移植手术患者的基线资料和随访资料,分析其临床特点,肾移植后LN再发及远期预后,并与原发病为非LN的肾移植患者进行比较。结果:LN组18例患者肾移植术后中位随访时间为52.8个月,其中有3例发生终末期肾病(ESRD),无一例死亡,肾移植后1年、5年、10年肾脏生存率为100%、88.9%、83.3%;对照组72例原发病为非LN患者肾移植术后的中位随访时间为58.5个月,其中有10例患者发生ESRD,1例死亡,肾移植后1年、5年、10年肾脏生存率为100%、93.1%、88.9%;两组患者肾脏生存率无统计学差异。LN组有1例患者在肾移植术后LN再发,但患者肾脏生存率未受影响。结论:LN患者肾移植的远期预后较好,肾移植手术对进入ESRD的LN患者是一个很好的选择。
Objective: To retrospectively analyze the clinical features and long-term prognosis of renal transplant recipients with lupus nephritis (LN). Methods: The baseline data and follow-up data of patients with definite diagnosis of LN and renal transplantation from 1994 to 2014 in our center were collected. The clinical features, recurrence of LN after renal transplantation and long-term prognosis were analyzed. LN kidney transplant patients were compared. Results: The median follow-up time of renal transplantation in 18 patients with LN was 52.8 months, of which 3 patients had end-stage renal disease (ESRD), none died, and the renal survival rates at 1 year, 5 years and 10 years after renal transplantation The median follow-up time was 58.5 months in 72 non-LN patients with primary disease in control group. ESRD occurred in 10 patients and 1 patient died after renal transplantation The 1-year, 5-year and 10-year renal survival rates were 100%, 93.1% and 88.9%, respectively. There was no significant difference in renal survival between the two groups. One patient in LN group relapsed after renal transplantation, but the renal survival rate was not affected. CONCLUSIONS: The long-term prognosis of renal transplantation in patients with LN is better. Renal transplantation is a good choice for LN patients entering ESRD.