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氟比洛芬酯脂微球注射液是一种新型非甾体类抗炎镇痛药,由脂微球和其所包裹的氟比洛芬酯组成。脂微球对其所包裹的药物具有靶向性,控制包裹药物的释放,易于跨越细胞膜从而促进药物吸收,进一步缩短起效时间。氟比洛芬酯脂微球注射液已用于围术期镇痛、癌性疼痛等。本文综述其药理作用和临床应用新进展。
Flurbiprofen ester lipid microsphere injection is a new non-steroidal anti-inflammatory analgesics, composed of lipid microspheres and the wrapped flurbiprofen axetil. Lipid microspheres have the targeting of the drugs they encapsulate, control the release of the encapsulated drugs, easily cross the cell membrane to promote drug absorption and further shorten the onset time. Flurbiprofen ester lipid microsphere injection has been used for perioperative analgesia, cancer pain and so on. This article reviews its pharmacological effects and clinical application of new progress.