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人工感染斯氏狸殖吸虫的家犬顿服吡喹酮80mg/kg和120mg/kg后24小时童虫活力与对照组相似,电镜下仅见吸盘轻度收缩,体表稍肿胀;200mg/kg顿服和80mg/kg及120mg/kg分3次服虫体变化相似,活力均较对照组减弱,电镜下见吸盘强烈收缩,表皮显著肿胀,肠内容物停滞;200mg/kg分3次服后大部分虫体丧失活力,挛缩为弓形,电镜下见体棘断裂,皮纹紊乱,皮泡形成,线粒体破坏;300mg/kg分3次服后全部童虫无活力,挛缩为哑铃形或向腹面卷曲,颜色灰白,电镜观察皮纹消失,皮泡溃破,糜烂剥落,基质中线粒体浓缩。对吡喹酮杀灭肺吸虫的可能机制及治疗幼虫寄生型肺吸虫病的合适剂量与疗程作了探讨。
Artemisia serrata dogs infected artificially infected domestic dogs Dayton served praziquantel 80mg / kg and 120mg / kg 24 hours after the worm activity similar to the control group, under the electron microscope, only mild contraction of the sucker, body surface slightly swollen; 200mg / kg Dayton Compared with the control group, the clothes and the 80mg / kg and 120mg / kg sub-3 worms changed in a similar manner. The ultrastructural changes of the sucker were observed under electron microscope. Some parasites lost their vitality and their contractions were arched. Electron microscopy showed body spines rupture, dermatoglyphosis, dermis formation and mitochondria destruction. After 300 mg / kg of 3 doses, all the parasites were non-viable and the contracture was dumbbell-shaped or curled to the ventral surface , Gray color, electron microscopy dermatoglyphics disappear, dermal bubble ulcer, erosion exfoliation, matrix mitochondria concentration. The possible mechanism of praziquantel to kill paragonimiasis and the suitable dose and course of treatment for larva parasitic paragonimiasis were discussed.