论文部分内容阅读
目的:分析凋亡抑制蛋白(IAP)Survivin在胃癌中的表达及和预后的相关性。方法:抽取佛山市第一人民医院消化内科2012年4月至2013年4月收治的50例胃癌患者作为甲组,另选择同期50例正常胃粘膜患者作为乙组,分析其Survivin的表达,及预后相关性。结果:(1)甲组高表达率是54.0%,高于乙组0%,组间比较,差异具有统计学意义(P<0.05)。(2)胃癌患者Survivin水平表达与肿瘤浸润深度、临床分期以及淋巴结转移等存在显著相关性;且临床分期、肿瘤直径、肿瘤浸润深度以及淋巴结转移、原癌基因人类表皮生长因子受体2(Her-2)表达、脏器转移、Survivin高表达等与预后效果有显著的相关性,差异具有统计学意义(P<0.05)。结论:胃癌患者的Survivin表达情况与病情进展、严重程度等有密切关系,可将其作为评估胃癌患者病情发展及预后效果的重要指标。
OBJECTIVE: To analyze the expression of Survivin, an inhibitor of apoptosis protein (IAP), in gastric cancer and its correlation with prognosis. Methods: Fifty patients with gastric cancer who were admitted to Department of Gastroenterology, First People’s Hospital of Foshan City from April 2012 to April 2013 were selected as Group A, and 50 patients with normal gastric mucosa were selected as Group B in the same period to analyze the expression of Survivin and Prognosis correlation. Results: (1) The high expression rate of group A was 54.0%, which was higher than that of group B (0%). The difference between the two groups was statistically significant (P <0.05). (2) There was a significant correlation between the expression of Survivin and the depth of invasion, clinical stage and lymph node metastasis in patients with gastric cancer. The clinical stage, tumor diameter, depth of tumor invasion and lymph node metastasis, the expression of the oncogene human epidermal growth factor receptor 2 (Her -2) expression, organ metastasis, high Survivin expression and prognosis were significantly correlated, the difference was statistically significant (P <0.05). Conclusion: The expression of Survivin in patients with gastric cancer is closely related to the progress and severity of the disease, which can be used as an important index to evaluate the prognosis and effect of gastric cancer patients.