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关于在一般人群中易感性的可能变异,目前了解尚少。近来的一些报告提出,普通异染色质的多态性与肿瘤的易感性之间有关联。本文拟讨论个体的特殊异染色质变异体与肿瘤发生有关的证据,以及这些变异体促使新生物转移的细胞遗传学变化的可能途径。异染色质表现为多态系统,在此系统中个体的染色体常表现为连续的变异(体积大小或荧光亮度),其位置亦有某些变化。用C-显带技术染色人类染色体,邻接于着丝粒处均有异染色质区,正常情况下在那些有大量异染色质的染色体中,大小变化特别明显的有1、9和16号染色体。异染色质区也可出现“倒位”;某
Little is known about possible variations in susceptibility in the general population. Recent reports suggest that there is a link between common heterochromatic polymorphisms and tumor susceptibility. This article discusses the evidence of the association of individual heterochromatin variants with oncogenesis and the possible ways in which these variants contribute to cytogenetic changes in neo-biotransformation. Heterochromatin appears as a polymorphic system in which individual chromosomes often exhibit continuous variation (volume or fluorescence intensity) and some changes in their location. Human chromosomes are stained with C-banding technology and have heterochromatic regions adjacent to the centromere. Under normal conditions, chromosomes 1, 9 and 16 are particularly noticeable in those with large amounts of heterochromatin . Heterochromatin region may also appear “inverted”;