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儿童急性淋巴细胞性白血病(ALL)的疗效已日趋提高,但尚有少数病例及部分复发者对多种治疗缺乏效应,即所谓“难治性”ALL。我们应用中剂量氨甲喋呤静脉注射诱导治疗难治性ALL 5例,均于短期内获得较好疗效。5例病人,男3例,女2例,年龄3月～14岁,平均年龄7.5岁。均为骨髓复发病人,其中3例并发中枢神经系统白血病(1例面瘫,共济失调,颅脑CT为多发性颅内肿块;另2例头疼、呕吐,脑脊液找到白血病细胞)。所有病人均采用多
The efficacy of childhood acute lymphoblastic leukemia (ALL) has been increasing, but there are a few cases and some relapsers lack of effect on a variety of treatments, the so-called “refractory” ALL. We applied mid-dose methotrexate intravenous injection therapy refractory ALL 5 cases, both in a short period of time to obtain a better effect. 5 patients, 3 males and 2 females, aged from 3 months to 14 years old, with an average age of 7.5 years. All were bone marrow recurrence patients, of which 3 cases complicated by central nervous system leukemia (1 cases of facial paralysis, ataxia, brain CT for multiple intracranial masses; the other 2 cases of headache, vomiting, CSF found leukemia cells). All patients are using more