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氨基乙酰无环鸟苷(a’-O-Glycylacyclovir)是无环鸟苷(ACV)的一种水溶性酯衍生物。ACV是一种作用较强和选择性较强的抗单纯疱疹病毒(HSV)1型、2型及水痘带状疱疹病毒药物。细胞培养中,ACV抗HSV-1和HSV-2的作用高于碘苷(IDU)、阿糖腺苷(Ara-A)和三氟胸苷(F_3T)。实验证明3%ACV眼膏治疗兔HSV-1上皮型角膜炎有效。进一步的临床研究证明3%ACV眼膏治疗角膜溃疡虽然较用碘苷治疗愈合的快,但其疗效为0.5%或1%IDU眼膏相似,治疗树枝状角膜炎的疗效与Ara-A相同。另外,对IDU或Ara-A耐药的角膜溃疡亦有效。
A’-O-Glycylacyclovir is a water-soluble ester derivative of acyclovir (ACV). ACV is a potent and selective anti-herpes simplex virus (HSV) type 1, 2 and varicella zoster virus drug. The effect of ACV against HSV-1 and HSV-2 was higher than that of IDU, Ara-A and F_3T in cell culture. Experiments show that 3% ACV eye ointment is effective in treating HSV-1 keratitis in rabbits. Further clinical studies have shown that 3% ACV eye ointment treatment of corneal ulcers although compared with iodine treatment of healing faster, but the effect of 0.5% or 1% IDU ointment similar to the treatment of dendritic keratitis and Ara-A the same effect. In addition, corneal ulcers resistant to IDU or Ara-A are also effective.