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目的探讨口腔人乳头状瘤病毒(HPV)感染与子宫颈癌及癌前病变的相关性。方法 2009年1月-2012年12月,选择在本市多家医院就诊的患者或健康体检者880例。用荧光定量PCR技术测定口腔HPV感染情况。结果 832例门诊患者中,口腔HPV阳性检出率为6.0%(50/832),其中宫颈HPV阳性占80.0%(40/50);宫颈疾病组HPV阳性率为27.3%(18/66);宫颈对照组HPV阳性率为5.8%(47/814),2组比较差异有统计学意义(P<0.05)。宫颈癌、CINⅠ、CINⅡ、CINⅢ组口腔HPV感染风险OR值分别为10.5(95%CI:3.6~30.6)、3.2(95%CI:1.2~8.4)、4.4(95%CI:1.6~12.1)和6.9(95%CI:4.3~11.1)。多元Logistic回归分析显示,提示性伴侣数>3个、口交频率高是口腔-宫颈HPV感染及宫颈病变的危险因素。结论口腔HPV携带者的宫颈HPV感染率较高,宫颈病变的患者HPV感染风险增高。
Objective To investigate the correlation between oral human papilloma virus (HPV) infection and cervical cancer and precancerous lesions. Methods From January 2009 to December 2012, 880 cases of patients or health examination patients were selected from multiple hospitals in the city. Fluorescent quantitative PCR was used to detect oral HPV infection. Results Among 832 outpatients, the positive rate of oral HPV was 6.0% (50/832), of which 80.0% (40/50) were cervical HPV. The HPV positive rate in cervical disease was 27.3% (18/66). The positive rate of HPV in cervical control group was 5.8% (47/814), the difference between the two groups was statistically significant (P <0.05). The odds ratios for oral HPV infection in cervical cancer, CINⅠ, CINⅡ and CINⅢgroup were 10.5 (95% CI: 3.6-30.6), 3.2 (95% CI 1.2-8.4), 4.4 6.9 (95% CI: 4.3 to 11.1). Multivariate logistic regression analysis showed that the number of sexual partners was> 3, and the high frequency of oral sex was the risk factor of oral-cervical HPV infection and cervical lesions. Conclusion Cervical HPV infection rate is higher in oral HPV carriers, and the risk of HPV infection in patients with cervical lesions is higher.