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在美国,糖尿病是晚期肾病的主要致病原因,通过激活肾素-血管紧张素系统(RAS)产生患肾病的风险。健康妇女使用口服避孕药(OC)可使RAS激活,但口服避孕药对糖尿病性肾病的作用尚不清楚。本文在92位妇女中调查其使用卡托普利后的肾血浆流量(RPF),作为RAS活性的指标。在包括114名新近诊断为1型糖尿病的女性队列中研究OC对肾病的影响,平均随访期为20.7年。
Diabetes mellitus is the leading cause of advanced kidney disease in the United States and at risk of developing kidney disease by activating the renin-angiotensin system (RAS). RAS is activated in healthy women using oral contraceptives (OCs), but the effect of oral contraceptives on diabetic nephropathy is unclear. This article investigated renal plasma flow (RPF) after its use of captopril in 92 women as an indicator of RAS activity. The impact of OC on nephropathy was studied in a cohort of 114 women who were newly diagnosed with type 1 diabetes, with an average follow-up of 20.7 years.