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目的观察前列地尔治疗老年急性脑梗死的临床疗效及对血清IL-6和TNF-α的影响。方法 2009年9月～2011年8月,192例急性脑梗死患者随机分为两组,观察组96例,采用前列地尔治疗;对照组96例采用复方丹参注射液治疗,对比观察治疗前后两组的临床疗效、血清IL-6和TNF-α的变化。结果观察组的显效率明显高于对照组(P﹤0.05),而两组总有效率比较,差异无统计学意义(P﹥0.05)。观察组治疗后血清IL-6和TNF-α水平明显下降(P﹤0.05);并且,观察组治疗后血清IL-6和TNF-α水平明显低于同期对照组水平(P﹤0.05),而对照组治疗前后血清IL-6和TNF-α水平比较变化不大(P﹥0.05)。结论前列地尔对老年急性脑梗死患者进行治疗,能够明显提高临床疗效,降低血清IL-6和TNF-α水平,值得临床推广应用。
Objective To observe the clinical efficacy of alprostadil in the treatment of senile acute cerebral infarction and its effect on serum IL-6 and TNF-α. Methods From September 2009 to August 2011, 192 patients with acute cerebral infarction were randomly divided into two groups: 96 cases in the observation group treated with alprostadil and 96 cases in the control group treated with compound salvia miltiorrhiza injection. The clinical efficacy, serum IL-6 and TNF-α changes. Results The effective rate of the observation group was significantly higher than that of the control group (P <0.05). There was no significant difference in the total effective rate between the two groups (P> 0.05). The levels of IL-6 and TNF-α in the observation group decreased significantly (P <0.05), and the levels of IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05) The levels of serum IL-6 and TNF-α in control group before and after treatment changed little (P> 0.05). Conclusion Alprostadil for the treatment of elderly patients with acute cerebral infarction, can significantly improve the clinical efficacy, lower serum levels of IL-6 and TNF-α, worthy of clinical application.