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对恶性胸水患者于胸腔闭式引流术后采用胸腔注入抗癌药物治疗，报告其疗效观察结果。３０例恶性胸水均经组织学或细胞学检查证实，均为单侧胸腔积液。随机分两组，每组１５例。观察组应用高聚金葡素４０００单位，顺铂６０～８０ｍｇ；对照组单用顺铂６０～８０ｍｇ。结果：观察组ＣＲ１０例，ＰＲ４例，总有效率９３．４％；对照组ＣＲ４例，ＰＲ９例，总有效率８６．７％；两组总有效率相近，而ＣＲ率差异有显著性（χ２＝４．８，Ｐ＜０．０５）。观察表明，胸腔闭式引流术后注药法较常规胸穿注药法，可提高疗效；高聚金葡素联用顺铂治疗恶性胸水，疗效优于单用顺铂治疗者，其远期疗效有待进一步观察。
Patients with malignant pleural effusions were treated with thoracic cavity injections of anticancer drugs after closed thoracic drainage, and the results of their observations were reported. Thirty cases of malignant pleural effusions were confirmed by histological or cytological examinations and all were unilateral pleural effusions. Randomly divided into two groups, each group of 15 cases. The observation group used 4000 units of hyperglycated staphylococci and 60-80 mg of cisplatin; the control group used 60-80 mg of cisplatin alone. Results: The observation group CR 10 cases, PR4 cases, the total effective rate was 93.4%; the control group CR4 cases, PR 9 cases, the total effective rate was 86.7%; the two groups had similar effective rate, and the CR rate difference was significant (χ2 =4.8, P<0.05). Observations showed that the injection method after closed thoracic drainage was more effective than conventional thoracentesis. Hyperhomocystasin combined with cisplatin was superior to cisplatin alone in the treatment of malignant pleural effusion. The efficacy needs further observation.