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目的分析对慢性收缩性心功能不全患者检测血浆B型利钠肽(BNP)与血清胱抑素水平的临床意义。方法 100例慢性收缩性心功能不全患者根据NYHA分级标准分为3组,健康查体者20例作为对照组。用免疫荧光法检测血清胱抑素、血浆BNP浓度,心脏彩超检测左心室射血分数等指标。结果慢性收缩性心功能不全患者血清胱抑素C、血浆BNP浓度显著高于对照组,且随着心力衰竭的加重而显著增加(P均<0.01)。结论联合检测血清胱抑素C、血浆BNP能够预测慢性收缩性心功能不全患者发生心肾综合征(cardiorenal syndrome,CRS)的可能性。
Objective To analyze the clinical significance of detecting plasma B-type natriuretic peptide (BNP) and serum cystatin levels in patients with chronic systolic heart failure. Methods 100 cases of patients with chronic systolic heart failure were divided into 3 groups according to NYHA grading standards and 20 healthy individuals were used as control group. Cystatin, plasma BNP concentration and left ventricular ejection fraction were detected by immunofluorescence. Results Serum levels of cystatin C and plasma BNP were significantly higher in patients with chronic systolic heart failure than those in control group and significantly increased with heart failure (all P <0.01). Conclusions Combined detection of serum cystatin C and plasma BNP can predict the occurrence of cardiorenal syndrome (CRS) in patients with chronic systolic dysfunction.