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[目的]探讨不同炮制方法的淫羊藿对小鼠耐缺氧能力的影响.[方法]采用小鼠常压缺氧模型,测定不同炮制方法的淫羊藿对缺氧小鼠惊觉时间、存活时间和死亡时装置内氧体积分数的影响,并测定给予不同炮制方法淫羊藿后缺氧小鼠血红蛋白含量.[结果]与阴性对照组比较,淫羊藿生药(10 g/kg)和制淫羊藿Ⅱ(10 g/kg)均能明显延长缺氧小鼠惊厥时间及存活时间,死亡时装置内氧体积分数均降低(P<0.05,P<0.01),制淫羊藿Ⅱ还能提高缺氧小鼠血红蛋白含量.[结论]淫羊藿生药及制淫羊藿Ⅱ可增强小鼠耐缺氧能力,其中制淫羊藿Ⅱ的效果更明显.
[Objective] To explore the effect of epimedium with different preparation methods on hypoxic tolerance in mice. [Methods] Using animal model of normobaric hypoxia to determine the time of awakening of epimedium to hypoxia mice by different processing methods. The influence of oxygen volume fraction within the device on survival time and death, and determination of hemoglobin content in hypoxic mice after administration of different methods of preparation Epimedium. [Results] Herba Epimedii (10 g/kg) was compared with the negative control group. Epimedium II (10 g/kg) significantly prolonged the convulsive time and survival time of hypoxic mice, and the oxygen content in the device decreased at the time of death (P<0.05, P<0.01). It can increase the hemoglobin content in hypoxic mice. [Conclusion] Herba Epimedium and Epimedium II can enhance the ability of mice to tolerate hypoxia, and the effect of Epimedium II is more obvious.