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复习了对视网膜与脉络膜血管渗透性的定量研究和营养物质超越血-视网膜屏障的交换。脉络膜内多孔状的毛细血管使低分子量物质很易渗透,钠的渗透性约为骨髂肌的50倍,因而脉络膜血管外间隙内的营养物质浓度高、周转快。但这种自由弥散受脉络膜上皮屏障和视网膜毛细血管的制约,其内皮细胞间有紧密连接,即使是对钠,渗透性也很低。吸收指数技术为血-视网膜屏障的数种载体系统提供了证据,己糖类、中性和碱性氨基酸类,以及单羧酸类,都与脑内所见极为相似。至少对葡萄糖和乳酸化物等载体,在血-视网膜屏障、视网膜色素上皮和视网膜毛细血管内皮的两侧均起作用,具有向内和向外的双向性。
Review of the quantitative study of retinal and choroidal vascular permeability and the transmutation of nutrients beyond the blood-retinal barrier. Porous capillaries within the choroid so that low-molecular weight substances easily penetrate the sodium permeability of about 50 times that of the bony iliac muscle, and therefore the choroidal vascular gap in the high concentration of nutrients, fast turnover. However, this free dispersion is restricted by the choroidal epithelial barrier and retinal capillaries, with tight junctions between endothelial cells, and even low permeability to sodium. Absorption index technology provides evidence of several carrier systems for the blood-retinal barrier. Hexose sugars, neutral and basic amino acids, and monocarboxylic acids are very similar to those seen in the brain. Vectors such as glucose and lactate act at least on both sides of the blood-retinal barrier, the retinal pigment epithelium, and the retinal capillary endothelium, with inward and outward bidirectionality at least.