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目的 为了探讨女性常见良性乳腺增生病和纤维腺瘤与雌激素受体 (ER)的相关性。方法 对本院 5 3例非癌性乳腺肿块均经切取或切除活检病理诊断证实 ,(含乳腺增生病 2 4例 ,纤维腺瘤 14例 ,乳头状瘤 7例 ,乳腺腺病 8例 ) ,采用荧光组织化学法进行ER检测。结果 在 5 3例非癌性乳腺肿块组织中总的ER阳性率为 41.5 %。其中乳腺增生病、乳腺纤维腺瘤、乳管内乳头状瘤和乳腺腺病的ER表达分别为 41.7% ,16 .7% ,5 7.1%和 75 .0 %。 <5 0岁的ER阳性率为 48.7% ;而≥ 5 0岁者为 2 1.4%。表明绝经期前的ER表达水平高于绝经期后者。结论 本组中乳腺增生病的ER表达高于纤维腺瘤 ,认为非癌性乳腺肿块病人中约 1/3强属于激素依赖性 ,特别绝经期前的病人ER表达高于绝经期后者。
Objective To investigate the relationship between common benign mammary gland hyperplasia and fibroadenoma and estrogen receptor (ER) in women. Methods Fifty-three cases of non-cancerous breast masses in our hospital were confirmed by biopsy or biopsy, including 24 cases of hyperplasia of mammary gland, 14 cases of fibroadenoma, 7 cases of papilloma and 8 cases of breast adenosis. ER detection by fluorescence histochemistry. Results The total ER positive rate was 41.5% in 53 non-cancerous breast masses. The expression of ER in breast hyperplasia, breast fibroadenoma, intraductal papilloma and breast adenosis were 41.7%, 16.7%, 51.1% and 75.0%, respectively. The ER positive rate of <50 years old was 48.7%, while that of> 50 years old was 21.4%. Pre-menopausal ER expression is higher than the latter menopausal. Conclusions ER in breast hyperplasia is higher than that of fibroadenoma in this group. About one-third of non-cancerous breast masses are hormone-dependent, especially in premenopausal women.