目的 :探讨心肌声学造影诊断高血压心肌微血管病变的可行性。材料和方法 :应用心肌声学造影测量 2 4例高血压病患者和 8例对照组注射潘生丁前后心肌的A值、β值和A·β值 ,并计算出A、β比值和冠脉微血管的血流储备(CMVFR)。结果 :与对照组比较 ,高血压病患者注射潘生丁后A、β和A·β值增加幅度明显降低 ,β比值以及CMVFR显著降低 ;A值与DBP、A·β值与SBP呈正相关 (r =0 .45 ,0 .3 9) ;RatioA、Ratioβ和CMVFR与SBP(r =-0 .44 ,-0 .48,-0 .5 7)、Ratioβ和CMVFR与DBP呈负相关 (r =-0 .45 ,-0 .47)。 结论 :高血压病患者心肌微血管储备功能受损 ,心肌声学造影可对心肌微血管病变的诊断提供帮助 Objective: To investigate the feasibility of myocardial contrast echocardiography in diagnosing myocardial microangiopathy in hypertensive patients. MATERIALS AND METHODS: The myocardial A, β and A · βwere measured before and after injection of dipyridamole in 24 hypertensive patients and 8 control subjects by myocardial contrast echocardiography, and the A, β ratio and coronary microvascular blood Flow Reserve (CMVFR). Results: Compared with the control group, the increase of A, β and A · β in hypertensive patients after injection of dipyridamole was significantly lower than that in the control group, and the β ratio and CMVFR decreased significantly. The values ​​of A, DBP and A · β were positively correlated with SBP (r = 0.45, 0.39; RatioA, Ratioβ, CMVFR and SBP (r = -0.44, -0.48, -0.57), Ratioβ and CMVFR were negatively correlated with DBP .45, -0.47). Conclusions: Myocardial microvascular reserve is impaired in hypertensive patients, and myocardial contrast echocardiography can help diagnose myocardial microangiopathy