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目的研究乳腺癌组织中c－met蛋白表达的意义。方法应用SP免疫组织化学方法对33例乳腺癌石蜡包埋组织作c－met多克隆抗体染色，以10例乳腺纤维腺癌作对照，数据用t检验、X检验和Fisher检验进行统计分析。结果乳腺癌组织中c－met蛋白阳性表达率显著高于对照组（P＜0．01）。c－met蛋白表达与组织学分级、淋巴结转移、临床分期显著相关，而与年龄、绝经状况、肿瘤大小无相关。结论c－met表达是乳腺癌患者重要的预后因素。
Objective To study the significance of c-met protein expression in breast cancer. Methods Immunohistochemistry SP method was used to stain c-met polyclonal antibody in paraffin-embedded tissues of 33 cases of breast cancer. 10 cases of breast fibroadenocarcinoma were used as controls. Data were analyzed by t test, X test and Fisher test. Results The positive expression rate of c-met protein in breast cancer tissue was significantly higher than that in control group (P<0.01). C-met protein expression was significantly associated with histological grade, lymph node metastasis, and clinical stage, but not with age, menopausal status, and tumor size. Conclusion c-met expression is an important prognostic factor for breast cancer patients.