目的：探索蜕皮激素是否能够减轻肺再灌注后脂质过氧化损伤。方法：应用肺再灌注损伤模型，大鼠颈静脉滴注蜕皮甾酮（３０ｍｇ．ｋｇ－１），检测湿肺干肺比重，测定肺组织丙二醛（ＭＤＡ）、超氧化物岐化酶（ＳＯＤ）含量，光镜观察肺组织病理变化。结果：蜕皮甾酮可降低肺组织ＭＤＡ，升高肺组织ＳＯＤ，降低湿肺干肺比重和改善肺组织病变。结论：蜕皮甾酮可减轻肺再灌注后脂质过氧化损伤，有一定的保护作用，值得进一步研究。 Objective: To explore whether ecdysone can reduce lipid peroxidation injury after lung reperfusion. Methods: The models of lung reperfusion injury were established. The content of ecdysterone (30 mg.kg-1) was instilled into the jugular vein of rats. The dry weight of lung and lung were measured. The contents of malondialdehyde (MDA), superoxide dismutase SOD), the pathological changes of lung tissue were observed with light microscope. Results: Ecdysterone decreased MDA in the lung tissue, increased SOD in the lung tissue, decreased the dry lung weight and improved lung tissue pathology. Conclusion: Ecdysterone can reduce lipid peroxidation injury after lung reperfusion, and has some protective effect, which deserves further study.