甲硝哒唑治疗牙周炎、龈缘炎、坏死性龈口炎等口腔慢性炎症,时有报道,但口服给药剂量较大,有不良反应,药物在牙周局部的浓度低。为了提高药物疗效,降低用药剂量,减少不良反应,我科与药局共同研制了可吸收性复方甲硝唑缓释膜,并试用于临床,获得较满意的效果。 Metronidazole treatment of periodontitis, gingivitis, necrotizing gingivostomatitis and other oral chronic inflammation, have been reported, but a large dose of oral administration, there are adverse reactions, the drug in the periodontal local concentration is low. In order to improve the efficacy of drugs, reduce the dosage and reduce adverse reactions, our department and the pharmacy co-developed absorbable compound metronidazole sustained-release membrane, and try it in clinic to obtain more satisfactory results.