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本文报告对以皮质类固醇治疗无效的慢性活动性溃疡性结肠炎患者用硫唑嘌呤治疗的对照试验。44例患者参加试验。除常规治疗外,24例用硫唑嘌呤2～2.5mg/kg,20例用安慰剂,疗程6个月。设立临床计分卡,记录症状、体征、乙状结肠镜检所见、生化和血液学检查结果,并据此每个月评定1次临床症状活动情况。试验期间所有患者在病情许可下,只要可能就减少激素用量。疗程结束后继续观察3个月,有15例停止试验,其中9例因副作用(7例用硫唑嘌呤治疗发生恶心,2例用安慰剂发生皮肤反应),硫唑嘌呤组1例因心肌梗塞死亡,5例在第1个月内不愿再治疗。余下29例,其中14例用安慰剂者,有3例因
This article reports a controlled trial of azathioprine treatment in patients with chronic active ulcerative colitis who are refractory to corticosteroid therapy. 44 patients participated in the trial. In addition to conventional treatment, 24 cases with azathioprine 2 ~ 2.5mg / kg, 20 cases with placebo, treatment for 6 months. Set up a clinical scorecard, record the symptoms and signs, sigmoid colonoscopy seen, biochemical and hematological examination results, and monthly assessment of the clinical symptoms of activity. During the trial all patients under the condition permit, as long as possible to reduce the amount of hormones. Three months after the end of the course of treatment, 15 patients stopped the trial, 9 of them were side-effects (7 nausea with azathioprine and 2 with placebo), 1 in the azathioprine group due to myocardial infarction Death, 5 patients in the first month do not want to re-treatment. The remaining 29 cases, of which 14 patients with placebo, 3 patients