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目的 确证回顾性研究发现二硫化碳 (CS2 )作业女工受孕能力受抑的现象 ,并探讨“受孕时间”作为标志生殖损伤筛选指标的可行性。方法 在回顾性研究现场对欲生育的女工受孕时间进行了前瞻性研究。结果 ( 1)2 5 7名接触组女工第一个月经周期受孕率为 2 7 2 % ,前三个月经周期累积受孕率为 5 8 7% ,一年内累积受孕率为93 7% ,均明显低于对照组 (分别为 3 5 8%、 69 1%和 97 0 % ,P值分别为 0 0 181、 0 0 0 40和 0 0 14 5 ) ;( 2 )仅女方接触或夫妻双方接触CS2 组的受孕率均低于夫妻双方均不接触CS2 的受孕率 ;夫妻双方接触与单纯女工接触CS2 ,受孕率无明显差异 ;( 3 )每名女工受孕时间与其接触CS2 浓度 (r =0 1198,P =0 0 2 4)及接触时间 (r =0 2 799,P =0 0 0 0 )呈正相关。结论 受孕时间可作为标志生殖损伤效应的初筛指标。
Objective To confirm the retrospective study found that CS2 female workers frustrated the ability to conceive and to explore the “pregnancy time” as a marker of reproductive injury screening index feasibility. Methods A prospective study was conducted on the time of conception of pregnant women who wanted to give birth in retrospective study. Results (1) In the 257 female workers, the pregnancy rate of the first menstrual cycle was 27.2%, the cumulative pregnancy rate of the first three menstrual cycles was 57.8%, and the cumulative pregnancy rate within one year was 93.7% Lower than the control group (35.8%, 69.1% and 97.0%, P values were 0 0 181, 0 0 0 40 and 0 0 14 5, respectively); (2) The conception rate of the female workers was lower than the conception rate of the CS2 without any contact with the CS2. There was no significant difference in the conception rate between the two couples when they were exposed to CS2. (3) P = 0 0 2 4) and contact time (r = 0 2 799, P = 0 0 0 0). Conclusion Conception time can be used as a primary screening index of reproductive injury.