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随着免疫学的飞速发展和免疫学理论在医学各领域的不断渗透,创伤免疫反应的研究近十年来有了长足的进步。现在人们已经了解到严重创伤后,机体各免疫功能均呈不同程度的抑制,主要包括:中性白细胞趋化性和吞噬能力降低,血浆纤维连接蛋白(FN)含量减少,补体激活并消耗,单核-巨噬细胞系统和自然杀伤细胞(NK)活性降低,T淋巴细胞总数减少且对有丝分裂原PHA和ConA反应性降低,T抑制细胞(Ts)与T辅助细胞(Th)比例失调,B淋巴细胞功能轻度抑制或正常,血清IgG浓度降低,IgM一般无明显改变。创伤免疫抑制是可逆的,
With the rapid development of immunology and the continuous infiltration of immune theory in various fields of medicine, the research on traumatic immune response has made great strides in recent ten years. Now people have learned that severe trauma, the body’s immune function showed varying degrees of inhibition, including: Neutrophil chemotaxis and phagocytosis decreased plasma Fibronectin (FN) content decreased, complement activation and consumption, single Nuclear-macrophage system and natural killer (NK) activity decreased, the total number of T lymphocytes decreased and the reactivity to mitogen PHA and ConA decreased, the proportion of T suppressor cells (Ts) to T helper cells (Th) Slight inhibition or normal cell function, serum IgG concentration decreased, IgM generally no significant change. Traumatic immunosuppression is reversible,